10th- "Scattered f*ing showers, my ass!" - Noah, 4314 BC

9th - "How the f* did you work that out?" - Pythagoras, 126 BC

8th- "You want WHAT on the f*ing ceiling?" - Michelangelo, 1566

7th- "Where did all those f*ing Indians come from?" -Custer,1877

6th- "It f*ing does so look like her!" - Picasso, 1926

5th- "Where the f* are we?" - Amelia Earhart, 1937

4th- "Any f*ing idiot could understand that." - Einstein, 1938

3rd- "What the f* was that?" - Mayor Of Hiroshima, 1945

2nd- "I need this parade like I need a f*ing hole in the head!" - JFK, 1963

1st- "Where the f* did all that water come from!" Capt of the Titanic, 1912

And... drum roll...
The most recent appropriate time for using the "F" word...

"Aw c'mon. Who the f* is going to find out?"- Martha Stewart